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| As an illustration, human SET7/9 has just lately been reported to methylate Lys189 within the common transcription issue TAF10, resulting in an elevated affinity for RNA polymerase II and transcriptional activation of certain TAF10-dependent genes 37 SET7/9 has additionally been reported to methylate p53, increasing the soundness of this brief lived tumor-suppressor protein 38 These observations counsel that we must always not narrowly define the SET-area proteins as histone lysine methyltransferases however as a substitute call them protein lysine methyltransferases. | |||
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